Fibroids

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Fibroids are benign (noncancerous) tumors of the smooth muscle cells of the uterus. They are are the most frequently seen tumors of the female reproductive system. Also known as uterine myomas, leiomyomas, or fibromas, fibroids are firm, compact tumors that are made of smooth muscle cells and fibrous connective tissue that develop in the uterus.

Fibroids are a common cause of abnormal uterine bleeding. Although some women are asymptomatic, others can present with excessive bleeding, pain, urinary symptoms and subfertility ultimately seeking treatment.

Fibroids can develop throughout the uterus:

Intramural – in the uterine wall
Submucosal – in the uterine lining
Subserosal – on the uterine surface

It is estimated that between 20 to 50 percent of women of reproductive age have fibroids, although not all are diagnosed. Some estimates state that up to 30 to 77 percent of women will develop fibroids sometime during their childbearing years, although only about one-third of these fibroids are large enough to be detected by a physician during a physical examination. In more than 99 percent of fibroid cases, the tumors are benign (non-cancerous). These tumors are not associated with cancer and do not increase a woman's risk for uterine cancer. They may range in size, from the size of a pea to the size of a softball or small grapefruit.

What causes fibroids?

While it is not clearly known what causes fibroids, it is believed that each tumor develops from an aberrant muscle cell in the uterus, which multiplies rapidly because of the influence of estrogen.

Women who are approaching menopause are at the greatest risk for fibroids because of their long exposure to high levels of estrogen. Women who are obese and of African-American heritage also seem to be at an increased risk, although the reasons for this are not clearly understood.

What are the symptoms of fibroids?

Some women who have fibroids have no symptoms, or have only mild symptoms, while other women have more severe, disruptive symptoms. Symptoms of uterine fibroids may include:

Heavy or prolonged menstrual periods
Bleeding between menstrual periods
Pelvic pain (caused as the tumor presses on pelvic organs)
Frequent urination
Low back pain
Pain during intercourse
A firm mass, often located near the middle of the pelvis, which can be felt by the physician

In some cases, the heavy or prolonged menstrual periods, or the abnormal bleeding between periods, can lead to iron-deficiency anemia, which also requires treatment.

How are fibroids diagnosed?

Fibroids are most often found during a routine pelvic examination. This, along with an abdominal examination, may indicate a firm, irregular pelvic mass to the physician. In addition to a complete medical history and physical and pelvic and/or abdominal examination, diagnostic procedures for uterine fibroids may include:

X-ray: Electromagnetic energy used to produce images of bones and internal organs onto film
Transvaginal ultrasound: An ultrasound test using a small instrument, called a transducer, that is placed in the vagina
Magnetic resonance imaging (MRI): A non-invasive procedure that produces a two-dimensional view of an internal organ or structure
Hysterosalpingography: X-Ray examination of the uterus and fallopian tubes that uses dye and is often performed to rule out tubal obstruction
Hysteroscopy: Visual examination of the canal of the cervix and the interior of the uterus using a viewing instrument (hysteroscope) inserted through the vagina
Endometrial biopsy: A procedure in which a sample of tissue is obtained through a tube which is inserted into the uterus
Blood test (to check for iron-deficiency anemia if heavy bleeding is caused by the tumor)

How are fibroids treated?

Since most fibroids stop growing or may even shrink as a woman approaches menopause, the physician may simply suggest "watchful waiting." With this approach, the physician monitors the woman's symptoms carefully to ensure that there are no significant changes or developments and that the fibroids are not growing. In women whose fibroids are large or are causing significant symptoms, treatment may be necessary. In general, treatment for fibroids may include:

Hysterectomy involves the surgical removal of the entire uterus. Fibroids remain the number one reason for hysterectomies in the United States.
Conservative surgical therapy uses a procedure called a myomectomy. With this approach, physicians will remove the fibroids, but leave the uterus intact to enable a future pregnancy.
Gonadotropin-releasing hormone agonists (GnRH Agonists) lower levels of estrogen and trigger a "medical menopause." Sometimes GnRH agonists are used to shrink the fibroid, making surgical treatment easier.
Anti-hormonal agents oppose estrogen (such as progestin and Danazol), and appear effective in treating fibroids. Anti-progestins, which block the action of progesterone, are also sometimes used.
Uterine artery embolization (UAE), also called uterine fibroid embolization, is a newer minimally-invasive (without a large abdominal incision) technique. The arteries supplying blood to the fibroids are identified, then embolized (blocked off). The embolization cuts off the blood supply to the fibroids, shrinking them. Physicians continue to evaluate the long-term implications of this procedure on fertility and regrowth of the fibroid tissue.
Anti-inflammatory painkillers are often effective for women who experience occasional pelvic pain or discomfort.