1. Franklin D. Lowy, MD

    • Department of Medicine
      Division of Infectious Diseases
    • Department of Pathology & Cell Biology
    Headshot

    Dr Franklin Lowy is professor of medicine and pathology in the Division of Infectious Diseases in the College of Physicians and Surgeons at Columbia University. His laboratory investigates the pathogenesis and epidemiology of Staphylococcus aureus and Staphylococcus epidermidis infections.

    CUMC crown logoFranklin D. Lowy, MD
    is accepting new patients.
    Call (212) 305-8039 for appointments.

    Provider Information

    Board Certifications

    • Infectious Disease
    • Internal Medicine

    Areas of Expertise

    • Bacterial Infection

    Primary Location

    • Herbert Irving Pavilion

      161 Fort Washington Ave
      Suite: 3-346
      New York, NY 10032
      Phone:
      (212) 305-3015
      Appointment:
      (212) 305-8039
      Fax:
      (212) 305-1754

    Insurance Programs

    Please contact the provider’s office directly to verify that your particular insurance is accepted.
    • AETNA [PPO] - Open
    • AETNA [HMO] - Open
    • Affinity Health Plan [Medicaid] - Open
    • Affinity Health Plan [HMO] - Open
    • Amerigroup [Medicare] - Open
    • Amerigroup [Medicaid] - Open
    • CIGNA [PPO] - Open
    • CIGNA [HMO] - Open
    • CIGNA [Columbia Employee POS] - Open
    • Empire Blue Cross/Blue Shield [HMO] - Open
    • Empire Blue Cross/Blue Shield [EPO] - Open
    • Empire Blue Cross/Blue Shield [Medicare] - Open
    • Health Insurance Plan of NY (HIP) [HMO] - Open
    • Health Insurance Plan of NY (HIP) [POS] - Open
    • Health Net (PHS) [HMO] - Open
    • Health Net (PHS) [POS] - Open
    • Health Net (PHS) [PPO] - Open
    • Local 1199 [Union] - Open
    • Medicare [Medicare] - Open
    • Neighborhood Health Providers [Medicaid] - Open
    • Oxford Health Plans [Medicare Advantage] - Open
    • Oxford Health Plans [Liberty HMO] - Open
    • Oxford Health Plans [Freedom HMO] - Open
    • Oxford Health Plans [Community Medicare] - Open
    • United Health Care [POS] - Open
    • United Health Care [PPO] - Open
    • United Health Care [Columbia Employee POS] - Open
    • United Health Care [EPO] - Open
    • United Health Care [HMO] - Open

    Biographical Detail

    Academic Appointments

    • Professor of Medicine at CUMC
    • Professor of Pathology & Cell Biology at CUMC

    Education And Training

      Education & Training

    • Columbia University College of Physicians & Surgeons
    • Internship: Harlem Hospital Center
    • Residency: Harlem Hospital Center
    • Fellowship: Albert Einstein Medical Center

    Gender

    Male

    Languages Spoken

    • English
  2. Research involves the pathogenesis and transmission of Staphylococcus aureus.

    Lab Projects

    • Studies on the pathogenesis of staphylococcal infections
      Recent projects have focused on the role of different S. aureus and S. epidermidis surface proteins as mediators of adherence to explanted left ventricular assist device (LVAD) material. The goal of these studies has been to characterize the role of these proteins in the initiation of device-related infections. A second series of studies have used a mouse post-influenza model for S. aureus pneumonia to investigate the pathogenesis of these life-threatening infections.  

    • Studies on the transmission of S. aureus among high-risk populations
      A household-based study is underway to investigate how CA-MRSA is spread in the predominantly Dominican population that surrounds Columbia University Medical Center. Genetic characterization of these isolates as they spread within the community will examine whether adaptive changes facilitate spread. The goal of these studies is to gain a better understanding of the factors that contribute to the dissemination of S. aureus within this population. A second component of this investigation is to examine the spread of a unique methicillin-susceptible S. aureus, strain ST398. This strain is prevalent in Northern Manhattan and is responsible for an increasing number of clinical infections. A second transmission study is underway to determine how CA-MRSA strains are introduced and spread into the NYS prison system. The study, performed at Sing Sing and Bedford Hills maximum-security prisons examines inmates at entry, during their stay and at release from the two prisons. Molecular epidemiologic techniques are used to characterize the predominant isolates in the two facilities. 

    • Studies on the epidemiology of ventricular assist device infections
      A multicenter prospective study examined the risk factors associated with the development of VAD-related infections. Molecular characterization of the isolates associated with these infections is underway. This study also identified clones of S. epidermidis that were found at geographically dispersed medical centers across the United States.

    Research Information

    NIH Grants

    Lab Members

    • Frank D. Lowy, MD
    • Rachel J. Gordon, MPH, MD
    • Anne-Catrin Uhlemann, MD, Ph.D
  3. publications

    • Lowy FD. Staphylococcus aureus infections. N Engl J Med. 1998;339:520-532.
    • Lowy FD. Antimicrobial resistance: The example of Staphylococcus aureus. J Clin Invest. 2003;111:1265-1273.
    • Gordon RJ, Lowy FD. Bacterial infections in drug users. N Engl J Med. 2005;353:1945-1954.
    • Furuya EY, Lowy FD. Antimicrobial-resistant bacteria in the community setting. Nature Microbiol Rev. 2006;4:36-45.
    • Gordon RJ, Quagliarello B, Lowy FD. Ventricular assist device-related infections. Lancet Infect Dis. 2006;6:426-37.
    • Lowy, F.D., Aiello, A.E., Bhat, M., Johnson-Lawrence, V.D., Lee, M., Burrell, E., Wright, L.N., Vasquez, G. and Larson, E.L. Staphylococcus aureus colonization and infection in New York State Prisons. J. Infect. Dis. 196:911-918, 2007
    • Arrecubieta, C., Lee, M., Macey, A., Foster, T.J. and Lowy, F.D. SdrF, a Staphylococcus epidermidis surface protein, binds type 1 collagen. J. Biol. Chem. 282:18767-18776, 2007
    • Lowy, F. D. Secrets of a superbug. Nat. Med.13:1418-1420, 2007
    • Arrecubieta, C., Francis, F.A.T.,von Bayern, M. P., Akashi, H., Deng, M.C., Naka, Y. and Lowy, F.D. SdrF, a Staphylococcus epidermidis surface protein, contributes to the initiation of ventricular assist device driveline-related infections. PLoS Pathogens 5:e1000411-1000424, 2009
    • Lee M.H., Arrecubieta C., Martin F.J., Prince A., Borczuk A.C. and Lowy F.D. A postinfluenza model of Staphylococcus aureus pneumonia. J Infect Dis 201:508-15, 2010
    • Gwizdala, R., Miller, M., Bhat, M., Vavagiakis, P., Henry, C., Neaigus, A., Shi, Q. and Lowy, F.D. Staphylococcus aureus among drug users: identification of hidden networks. Amer. J. Pub. Health. In Press 2011
    • Lowy, F.D. Staphylococcal Infections In: Harrison’s Principles of Internal Medicine, 18th edition. Editors: A. S. Fauci, E. Braunwald, D.L. Casper, S. L. Hauser, D. L. Longo, J. L. Jameson and J. Loscalzo. The McGraw-Hill Companies, Inc., In Press 2011