Franklin D. Lowy, MD
- Department of Medicine
Division of Infectious Diseases
- Department of Pathology & Cell Biology
Dr Franklin Lowy is professor of medicine and pathology in the Division of Infectious Diseases in the College of Physicians and Surgeons at Columbia University. His laboratory investigates the pathogenesis and epidemiology of Staphylococcus aureus and Staphylococcus epidermidis infections.
- Internal Medicine
- Infectious Disease
Areas of Expertise
- Bacterial Infection
Herbert Irving Pavilion161 Fort Washington Avenue
New York, NY 10032
- (212) 305-3015
- (212) 305-8039
- (212) 305-1754
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- Aetna [HMO] - Open
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- Amerigroup [Medicaid] - Open
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- Empire Blue Cross Blue Shield [HMO] - Open
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- Health Insurance Plan of NY (HIP) [HMO] - Open
- Health Insurance Plan of NY (HIP) [POS] - Open
- Health Net (PHS) [HMO] - Open
- Health Net (PHS) [POS] - Open
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- United Healthcare [HMO] - Open
- United Healthcare [POS] - Open
- United Healthcare [PPO] - Open
- United Healthcare [Columbia University Employee Plan] - Open
- United Healthcare [EPO] - Open
- Professor of Medicine at CUMC
- Professor of Pathology & Cell Biology at CUMC
Education And Training
- Columbia University College of Physicians & Surgeons
- Internship: Harlem Hospital Center
- Residency: Harlem Hospital Center
- Fellowship: Albert Einstein Medical Center
Education & Training
- Department of Medicine
Research involves the pathogenesis and transmission of Staphylococcus aureus.
Studies on the pathogenesis of staphylococcal infections
Recent projects have focused on the role of different S. aureus and S. epidermidis surface proteins as mediators of adherence to explanted left ventricular assist device (LVAD) material. The goal of these studies has been to characterize the role of these proteins in the initiation of device-related infections. A second series of studies have used a mouse post-influenza model for S. aureus pneumonia to investigate the pathogenesis of these life-threatening infections.
Studies on the transmission of S. aureus among high-risk populations
A household-based study is underway to investigate how CA-MRSA is spread in the predominantly Dominican population that surrounds Columbia University Medical Center. Genetic characterization of these isolates as they spread within the community will examine whether adaptive changes facilitate spread. The goal of these studies is to gain a better understanding of the factors that contribute to the dissemination of S. aureus within this population. A second component of this investigation is to examine the spread of a unique methicillin-susceptible S. aureus, strain ST398. This strain is prevalent in Northern Manhattan and is responsible for an increasing number of clinical infections. A second transmission study is underway to determine how CA-MRSA strains are introduced and spread into the NYS prison system. The study, performed at Sing Sing and Bedford Hills maximum-security prisons examines inmates at entry, during their stay and at release from the two prisons. Molecular epidemiologic techniques are used to characterize the predominant isolates in the two facilities.
Studies on the epidemiology of ventricular assist device infections
A multicenter prospective study examined the risk factors associated with the development of VAD-related infections. Molecular characterization of the isolates associated with these infections is underway. This study also identified clones of S. epidermidis that were found at geographically dispersed medical centers across the United States.
Project Dates: 11-Feb-13 to 31-Jan-15
Project Dates: 15-Aug-09 to 31-Jul-14
Project Dates: 15-Dec-08 to 30-Nov-14
- Frank D. Lowy, MD
- Rachel J. Gordon, MPH, MD
- Anne-Catrin Uhlemann, MD, Ph.D
- Lowy FD. Staphylococcus aureus infections. N Engl J Med. 1998;339:520-532.
- Lowy FD. Antimicrobial resistance: The example of Staphylococcus aureus. J Clin Invest. 2003;111:1265-1273.
- Gordon RJ, Lowy FD. Bacterial infections in drug users. N Engl J Med. 2005;353:1945-1954.
- Furuya EY, Lowy FD. Antimicrobial-resistant bacteria in the community setting. Nature Microbiol Rev. 2006;4:36-45.
- Gordon RJ, Quagliarello B, Lowy FD. Ventricular assist device-related infections. Lancet Infect Dis. 2006;6:426-37.
- Lowy, F.D., Aiello, A.E., Bhat, M., Johnson-Lawrence, V.D., Lee, M., Burrell, E., Wright, L.N., Vasquez, G. and Larson, E.L. Staphylococcus aureus colonization and infection in New York State Prisons. J. Infect. Dis. 196:911-918, 2007
- Arrecubieta, C., Lee, M., Macey, A., Foster, T.J. and Lowy, F.D. SdrF, a Staphylococcus epidermidis surface protein, binds type 1 collagen. J. Biol. Chem. 282:18767-18776, 2007
- Lowy, F. D. Secrets of a superbug. Nat. Med.13:1418-1420, 2007
- Arrecubieta, C., Francis, F.A.T.,von Bayern, M. P., Akashi, H., Deng, M.C., Naka, Y. and Lowy, F.D. SdrF, a Staphylococcus epidermidis surface protein, contributes to the initiation of ventricular assist device driveline-related infections. PLoS Pathogens 5:e1000411-1000424, 2009
- Lee M.H., Arrecubieta C., Martin F.J., Prince A., Borczuk A.C. and Lowy F.D. A postinfluenza model of Staphylococcus aureus pneumonia. J Infect Dis 201:508-15, 2010
- Gwizdala, R., Miller, M., Bhat, M., Vavagiakis, P., Henry, C., Neaigus, A., Shi, Q. and Lowy, F.D. Staphylococcus aureus among drug users: identification of hidden networks. Amer. J. Pub. Health. In Press 2011
- Lowy, F.D. Staphylococcal Infections In: Harrison’s Principles of Internal Medicine, 18th edition. Editors: A. S. Fauci, E. Braunwald, D.L. Casper, S. L. Hauser, D. L. Longo, J. L. Jameson and J. Loscalzo. The McGraw-Hill Companies, Inc., In Press 2011